Cabergoline Dostinex: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

There were maternotoxic effects but no teratogenic effects in mice given cabergoline at doses up to 8 mg/kg/day (approximately 55times the maximum recommended human dose) during the period of organogenesis. Carcinogenicity studies were conducted in mice and ratswith cabergoline given by gavage at doses up to 0.98 mg/kg/day and 0.32 mg/kg/day,respectively. These doses are 7 times and 4 times the maximum recommended humandose calculated on a body surface area basis using total mg/m /week in rodentsand mg/m /week for a 50 kg human. Cabergoline (that is most famous sold under trade name Cabaser and Dostinex – but there are many others), which is an ergot derivative, is a potent dopamine receptor agonist on D2 receptors.

• If you have not had dopamine medications before, the final dose is usually between 2-4mg but if Cabaser is being used with levodopa you may take up to 6mg/day.
• It also has some off-label medical applications in treating restless leg syndrome and as a supplementary drug for people taking SSRI antidepressant drugs to reduce the libido-crushing effects of those medications.
• Do not drive, use any tools or machines or engage in activities requiring mental alertness or coordination if you experience these symptoms until they have resolved completely.
• Cabergoline is a dopamine-related drug – we can call it a dopamine agonist.
• If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Dosage may be increased by 0.25 mg twiceweekly up to a dosage of 1 mg twice a week according to the patient’s serum prolactin level. Before initiating treatment, cardiovascular evaluation shouldbe performed and echocardiography should be considered to assess for valvulardisease. 👉 The pharmacodynamic actions of cabergoline not correlated with the therapeutic effect only relate to blood pressure decrease.

It can cause dizziness, especially during the first few days of treatment. Cabaser should always be taken as prescribed by your doctor. They will be able to decide the best dose suited for you according to your condition and other comorbidities. Cabergoline is considered the best tolerable option for hyperprolactinemia treatment although the newer and less tested quinagolide may offer similarly favourable side effect profile with quicker titration times. In my experience, if I want to get my hands on Cabergoline reliably, quickly, and affordably, then I’ll go to my favored research chemical supplier and have it in my hands within a day or two with no legal worries. PCT of 4 to 6 weeks is still recommended with or without Cabergoline.

The recommended frequency of routineechocardiographic monitoring is every 6 to 12 months or as clinically indicatedwith the presence of signs and symptoms such as edema, new cardiac murmur, dyspnea, or congestive heart failure. Cabergoline is a dopaminergic ergoline derivative endowed with potent and long-lasting dopamine D2 receptor agonist properties. In rats the compound, acting at D2 dopamine receptors on pituitary lactotrophic cells, decreases PRL secretion at oral doses of 3-25 mcg/kg, and in vitro at a concentration of 45 pg/ml.

The effect was mainly evident in the first weeks of therapy. All adverse events occurring with an incidence of 3% or higher in any treatment group are reported in the tables. The recommended dosage of Cabaser tablets for initiation of therapy is 0.25 mg twice a week. Dosage increases should not occur more rapidly than every 4 weeks, so that the physician can assess the patient’s response to each dosage level. If the patient does not respond adequately and no additional benefit is observed with higher doses, the lowest dose that achieved maximal response should be used and other therapeutic approaches considered.

Medication package inserts

Major The use of cabergoline is contraindicated in patients with uncontrolled hypertension. Hypersensitive (allergic) to Cabaser, to other medicines called ergot alkaloids, (e.g. pergolide, bromocriptine, lisuride, ergotamine or ergometrine) or to any of the other ingredients in the tablet. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Your blood will need to be tested on a regular basis to measure your prolactin levels. Your doctor will perform tests to make sure you do not have conditions that would prevent you from safely using cabergoline.

Care should be taken when taking Cabaser with other drugs known to lower blood pressure. Your doctor will do some tests every 6 to 12 months while you are taking Cabaser to help prevent unwanted side effects. For example, chest x-rays, physical examinations, blood tests and heart monitoring. Such tests can detect leaky and/or narrowed valves of the heart and any scarring or thickening of the lungs.

While you are taking Cabaser

Patients should be regularly monitored for the development of impulse control disorders. Dose reduction/tapered discontinuation should be considered if such symptoms develop. In some cases, symptoms or manifestations of cardiac valvulopathy improved after discontinuation of cabergoline. https://www.clearlab.com/index.php/tamoxifen-an-overview-4/ Postmarketing cases of pleural, pericardial, andretroperitoneal fibrosis have been reported following administration ofDOSTINEX. Some reports were in patients previously treated with other ergotinicdopamine agonists. DOSTINEX should not be used in patients with a history ofcardiac or extracardiac fibrotic disorders.

Medical Links

Chest x-ray examination is recommended in cases of unexplained ESR increases to abnormal values. The safety and efficacy of cabergoline has not been investigated in children as Parkinson’s disease does not affect this population. In addition, in case of pronounced central nervous system effects the administration of dopamine antagonist drugs may be advisable. Medicines used to treat mental illness (e.g. antipsychotic medicines like chlorpromazine, haloperidol).